The expression and significance of chemokines eotaxin and RANTES in the rat model of allergic rhinitis / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 1069-1071, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-746448
ABSTRACT
OBJECTIVE@#To explore the expression and significance of Eotaxin and RANTES in the rat model of allergic rhinitis (AR).@*METHOD@#20 female SD rats in 6-7 weeks were randomly divided into control group and AR group (n = 10, respectively). AR rat model was made with ovalbumin stimulation. To detect pathological changes in mucosa and chemokine Eotaxin, RANTES in their nasal and lung tissues after execution.@*RESULT@#Compared with the control group, Lung EOS cell counted higher in AR group and the difference was significant (P < 0.01); the AR rats nasal mucosa and lung tissue of Eotaxin, RANTES expression was significantly increased (P < 0.01).@*CONCLUSION@#There exist high expression of Eotaxin, RANTES, infiltration of eosinophils in nasal and lung tissue of model rats with allergic rhinitis, inferring that the upper and lower respiratory tract inflammatory response has obvious consistency.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Ratos Sprague-Dawley
/
Quimiocina CCL5
/
Modelos Animais de Doenças
/
Quimiocina CCL11
/
Rinite Alérgica
/
Pulmão
/
Metabolismo
/
Mucosa Nasal
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Ano de publicação:
2014
Tipo de documento:
Artigo
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