Expression of BDNF mRNA in nasal mucosa with allergic rhinitis rat model / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 224-226, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-746626
ABSTRACT
OBJECTIVE@#To evaluate the role of brain-derived neurotrophic factor (BDNF) in allergic rhinitis of rat.@*METHOD@#Thirty SD rats free of disease were randomly divided into two groups. A model of allergic rhinitis rat was established by using ovalbumin intraperitoneal immunization and intranasal antigen challenge. The nasal mucosa from 18 out of 20 AR models as well as 10 normal controls were studied for expression of BDNF mRNA by reverse transcription-polymerase chain reaction (RT-PCR).@*RESULT@#BDNF/beta-actin ratio in AR models was significantly higher than control (0.49+/-0.07 vs 0.28+/-0.01, P<0.05).@*CONCLUSION@#BDNF played an important role in the development of allergic rhinitis of rat.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
RNA Mensageiro
/
Rinite Alérgica Perene
/
Ratos Sprague-Dawley
/
Fator Neurotrófico Derivado do Encéfalo
/
Modelos Animais de Doenças
/
Genética
/
Metabolismo
/
Mucosa Nasal
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Ano de publicação:
2010
Tipo de documento:
Artigo
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