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The study on the relationship between human papillomavirus infection and pathogenesis of nasal inverted papilloma and its malignant transformation / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery ; (24): 209-211, 2010.
Artigo em Chinês | WPRIM | ID: wpr-746631
ABSTRACT
OBJECTIVE@#To investigate the relationship between human papillomavirus (HPV) infection and pathogenesis of nasal inverted papilloma (NIP) and its malignant transformation.@*METHOD@#Fifty-seven cases of NIP were divided into 2 groups benign group, squamous cell carcinoma (SCC) arising in NIP group (malignancy group). HPV-DNA types of 6, 11, 16, 18 were detected by polymerase chain reaction (PCR) in 57 cases of NIP. Thirty cases of nasal polyps were control.@*RESULT@#Total positive rate of HPV in NIP was 64.9% (37/57). The positive rate of benign group was 60% (27/45), all with single and low risk HPV11 type infection. The positive rate of malignancy group were was 83.3% (10/12), and the majority were HPV16 and HPV18. Five cases had double infection (4 with HPV16 and HPV 18, 1 with HPV11 and HPV18), four had single HPV16 infection, another one had single HPV11 infection. However, HPV-DNA was not detected in any cases of nasal polyps.@*CONCLUSION@#Infection of HPV-DNA has an important effect in pathogenesis of NIP. Meanwhile, there maybe a close relationship between high risk HPV16 type and HPV18 type and malignant transformation of NIP.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Papillomaviridae / Patologia / Virologia / Transformação Celular Neoplásica / Neoplasias Nasais / Papiloma Invertido / Infecções por Papillomavirus Tipo de estudo: Estudo de etiologia Limite: Adulto / Idoso / Aged80 / Feminino / Humanos / Masculino Idioma: Chinês Revista: Journal of Clinical Otorhinolaryngology Head and Neck Surgery Ano de publicação: 2010 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Papillomaviridae / Patologia / Virologia / Transformação Celular Neoplásica / Neoplasias Nasais / Papiloma Invertido / Infecções por Papillomavirus Tipo de estudo: Estudo de etiologia Limite: Adulto / Idoso / Aged80 / Feminino / Humanos / Masculino Idioma: Chinês Revista: Journal of Clinical Otorhinolaryngology Head and Neck Surgery Ano de publicação: 2010 Tipo de documento: Artigo