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Expression and relationship of EBV LMP1, COX-2 and VEGF-C in nasopharyngeal carcinoma / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery ; (24): 126-128, 2010.
Artigo em Chinês | WPRIM | ID: wpr-746637
ABSTRACT
OBJECTIVE@#To evaluate the expression of vascular endothelial growth factor C (VEGF-C), Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1), cyclooxygenase-2 (COX-2) in nasopharyngeal carcinoma (NPC).@*METHOD@#LMP1, COX-2 and VEGF-C were detects by immunohistochemical staining for 57 case NPC tissue.@*RESULT@#The positives rates of LMP1, COX-2 and VEGF-C detected by immunohistochemical staining were 49.1% (28/57), 75.4% (43/57) and 59.6% (34/57), respectively. The expression of LMP1, COX-2 and VEGF-C were correlated to each other in NPC (P < 0.05).@*CONCLUSION@#LMP1 and COX-2 may induce expression of VEGF-C directly or LMP1 induce expression of VEGF-C by induce COX-2 expression, may contribute to lymph metastasis and develop NPC.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Proteínas da Matriz Viral / Neoplasias Nasofaríngeas / Fator C de Crescimento do Endotélio Vascular / Ciclo-Oxigenase 2 / Metabolismo / Estadiamento de Neoplasias Limite: Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Chinês Revista: Journal of Clinical Otorhinolaryngology Head and Neck Surgery Ano de publicação: 2010 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Proteínas da Matriz Viral / Neoplasias Nasofaríngeas / Fator C de Crescimento do Endotélio Vascular / Ciclo-Oxigenase 2 / Metabolismo / Estadiamento de Neoplasias Limite: Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Chinês Revista: Journal of Clinical Otorhinolaryngology Head and Neck Surgery Ano de publicação: 2010 Tipo de documento: Artigo