Expression and significance of IGF-IR and PKC in laryngeal squamous cell carcinoma / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 152-155, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-746653
ABSTRACT
OBJECTIVE@#To investigate the expression of IGF-IR and PKC and their clinical significance in laryngeal squamous cell carcinoma(LSCC).@*METHOD@#The expression of IGF-IR and PKC protein were detected by immunohistochemistry and Western blot in 60 cases of LSCC, 25 cases of adjacent non-tumorous laryngeal epithelium and 10 cases of normal laryngeal epithelium.@*RESULT@#The positive rate of IGF-IR and PKC expression in LSCC were significantly higher than that in normal laryngeal epithelium and adjacent non-tumorous laryngeal epithelium (P < 0.05). IGF-IR positive expression were increased more in cases with stage III-IV, cervical lymph node metastasis and well differentiation than that in cases with stage I-II, non-lymph node metastasis and poor/mediate differentiation, respectively (P < 0.05). The positive rate of PKC in LSCC were correlated with clinical stage and cervical lymph node metastasis. There was a correlation between the expression of IGF-IR and PKC in LSCC.@*CONCLUSION@#The overexpression of IGF-IR and PKC in the laryngeal carcinoma may play an important role in the carcinogenesis and development of LSCC. It is suggested that detecting the expression of IGF-IR and PKC can be used for early diagnosis and treatment of LSCC.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Proteína Quinase C
/
Carcinoma de Células Escamosas
/
Neoplasias Laríngeas
/
Receptor IGF Tipo 1
/
Metabolismo
Tipo de estudo:
Estudo de rastreamento
Limite:
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Ano de publicação:
2010
Tipo de documento:
Artigo
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