Your browser doesn't support javascript.
loading
Electrophysiologic study of murine spiral ganglion neurons / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery ; (24): 1038-1043, 2009.
Artigo em Chinês | WPRIM | ID: wpr-746675
ABSTRACT
OBJECTIVE@#To explore the nature of voltage dependent ion channels and basic electrophysiological characteristics of cochlear spiral ganglion neurons of apical and basal turn by patch clamp techniques of whole cell configure on murine spiral ganglion neurons.@*METHOD@#Different voltage dependent ionic currents were recorded with patch clamp techniques of whole cell configure on the condition of different internal electrode solution, blockers and stimulus protocol.@*RESULT@#Inward sodium channel current (I(Na)), hyperpolarization-activated inward cationic current (Ih), outward delay rectification potassium current (I(K)) and outward transient potassium current (I(A)) were recorded ,significant difference of electrophysiological characteristics of I(A) and I(K) was found between apical and basal turns (P < 0.05).@*CONCLUSION@#Various ionic currents are recorded, which shows that spiral ganglion neurons have the base of ionic channels to complete formation,conduction and modulation of action potential for auditory information transduction, the difference of electrophysiological characteristics between apical and basal turns contributes to the course of hearing formation.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fisiologia / Células Cultivadas / Gânglio Espiral da Cóclea / Técnicas de Patch-Clamp / Canais Iônicos / Potenciais da Membrana / Camundongos Endogâmicos / Neurônios Limite: Animais Idioma: Chinês Revista: Journal of Clinical Otorhinolaryngology Head and Neck Surgery Ano de publicação: 2009 Tipo de documento: Artigo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fisiologia / Células Cultivadas / Gânglio Espiral da Cóclea / Técnicas de Patch-Clamp / Canais Iônicos / Potenciais da Membrana / Camundongos Endogâmicos / Neurônios Limite: Animais Idioma: Chinês Revista: Journal of Clinical Otorhinolaryngology Head and Neck Surgery Ano de publicação: 2009 Tipo de documento: Artigo