Fast onset of action of sublingual immunotherapy in dust mite caused allergic rhinoconjunctivitis / 临床耳鼻咽喉头颈外科杂志

ABSTRACT

OBJECTIVE@#To investigate whether sublingual immunotherapy(SLIT) can take effect during the early phase in allergic rhinoconjunctivitis.@*METHOD@#Sixty subjects diagnosed as allergic rhinoconjunctivitis were enrolled and divided into the SLIT group and the control group. The daily symptom and medication scores were recorded and analyzed.@*RESULT@#After 4 weeks treatments, the daily symptoms score had significantly reduced in SLIT group(P 0.05). Whereas, the daily symptoms score and daily medication score in control group had shown changes with fluctuations. The correlation analysis had indicated that the daily medication score in the control group had a significant negative correlation with the daily symptom score (F = 554.9, P < 0.01). No serious adverse events occurred in this study.@*CONCLUSION@#SLIT could take effect in patients with allergic rhinoconjunctivitis sensitive to house dust mite as fast as the 4th week.