Expression of Th17 related cell factors and its significance in CRSsNP / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 946-948, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-747339
ABSTRACT
OBJECTIVE@#To detect the expression of Th17 nuclear factor RORC and cytokines IL-17A and IL-22 and neutrophil marker MPO and their correlations with CRSsNP.@*METHOD@#RT-PCR was used to detect mRNA expression of RORC, IL-17A and IL-22. Immunohistochemistry was used to assess the IL-17A positive cells in CRSsNP and control. ELISA was used to detect the expression of MPO.@*RESULT@#CRSsNP had higher mRNA expression of RORC, IL-17A and IL-22 and increased protein expression of MPO. The mRNA expression of RORC, IL-17A and IL-22 was positively correlated with each other but none of them was correlated with the expression of MPO in CRSsNP and control.@*CONCLUSION@#Both Th17 and neutrophils contribute to the pathogenesis of CRSsNP, however, the neutrophil infiltration may not be recruited by Th17 cytokines.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Sinusite
/
Doença Crônica
/
Interleucinas
/
Interleucina-17
/
Infiltração de Neutrófilos
/
Alergia e Imunologia
/
Membro 3 do Grupo F da Subfamília 1 de Receptores Nucleares
/
Células Th17
/
Neutrófilos
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Ano de publicação:
2012
Tipo de documento:
Artigo
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