Chemical Modification of RBC Surface Antigen with Methoxy Polyethylene Glycol / 대한임상병리학회지
Korean Journal of Clinical Pathology
;
: 723-728, 1999.
Artigo
em Coreano
| WPRIM
| ID: wpr-74752
ABSTRACT
BACKGROUND:
Today, blood group antigens are a strong barrier of safe transfusion. We evaluated the change of agglutinability of antibody to RBC surface antigen before and after activated methoxy polyethylene glycol (mPEG) modification.METHODS:
We collected blood from healthy volunteers and the blood were treated by activated mPEG (MW 5,000, Sigma, USA). Agglutinability of RBC was measured using anti-sera (Green Cross, Korea) in ABO and Rh(D) groups, and compared the agglutinability changes before and after mPEG treatment.RESULTS:
The agglutinability of Rh(D) surface antigen (n=20) was disappeared after mPEG treatment. However, ABO antigens showed variable agglutinability against antisera, some of which showed no change at all.CONCLUSIONS:
In the case of Rh(D) antigen, it would be useful to apply mPEG treated RBCs for clinical use, if the safety problem were solved. But in the case of ABO antigen, the more evaluation of the condition of reaction and the concentration of mPEG should be needed.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Polietilenoglicóis
/
Antígenos de Grupos Sanguíneos
/
Substitutos Sanguíneos
/
Polietileno
/
Voluntários Saudáveis
/
Soros Imunes
/
Antígenos de Superfície
Idioma:
Coreano
Revista:
Korean Journal of Clinical Pathology
Ano de publicação:
1999
Tipo de documento:
Artigo
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