Correlative study of nuclear factor-kappa B subunit p50 activity and IL-4 gamma-IFN expression in nasal polyps / 临床耳鼻咽喉头颈外科杂志

ABSTRACT

OBJECTIVE@#To explore the possible regulation mechanism of nuclear factor-kappa B subunit p50 on Th1/Th2 cytokine in nasal polyps.@*METHOD@#The expression of IL-4, gamma-IFN and p50 were examined by the method of immunohistochemistry staining in 40 cases of nasal polyps and 20 normal subjects, and the linear correlations between activity of p50 and IL-4, gamma-IFN were evaluated.@*RESULT@#The expression of p50 mainly distribute in the cytoplasm of epithelia, inflammatory cell and the epithelia of gland. The expression of IL-4 and the activity of p50 was increased significantly in nasal polyps (all P0.05). Pearson correlation analysis demonstrated that p50 nuclear-presented closely correlation with IL-4 level, but not gamma-IFN. The correlation coefficient was 0.70 for p50 and IL-4 (P0.05).@*CONCLUSION@#The activity of p50 in nasal polyps is increased significantly. The activation of p50 may play an important role in the imbalance of Th1/Th2-typed cytokines by upregulating the level of IL-4.