Effect of allergic factors on chronic rhinosinusitis / 临床耳鼻咽喉头颈外科杂志

ABSTRACT

OBJECTIVE@#To explore the correlation between allergic factors and chronic rhinosinusitis, and discuss its effects on the development of illness.@*METHOD@#One hundred and one cases were selected to detect allergic serum relative index: the concentration of serum TIgE, specific IgE semi-quantitative test, the concentration of serum ECP as well as inquiring medical record, Lund-Mackay CT system scoring.@*RESULT@#The concentration of serum TIgE and serum ECP in CRS was higher than those in control (P < 0.01). The increased proportion of serum TIgE and serum ECP was significantly different among clinical stages (P < 0.05) and between the cases with and without prior sinus surgery (P < 0.05). CT scores of the cases with serum TIgE and serum ECP increased were significantly higher than those without serum TIgE and serum ECP increased. The strong positive rate in CRS was significantly different among clinical stages (P < 0.05). The strong positive rate increased significantly in the cases with prior sinus surgery (P < 0.05). CT scores in the cases with strong positive allergen were significantly higher than that in the cases without positive allergen (P < 0.05).@*CONCLUSION@#These results suggest that allergic factors make some negative effect on the severity of CRS and are the index for the severity and worse prognosis of illness.