Effects of intranasal budesonide on the expression of c-fos and c-myc in nasal polyps / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 55-57, 2008.
Artigo
em Chinês
| WPRIM
| ID: wpr-747547
ABSTRACT
OBJECTIVE@#To investigate the effect of intranasal glucocorticoids treatment on the expression of c-fos and c-myc nasal polyps.@*METHOD@#Immunohistochemistry method was used to determine c-fos and c-myc expression in nasal polyps from patients with topical steroids treatment for 10-12 weeks and untreated patients.@*RESULT@#The rate of c-fos expressing cases was 15% and the rate of c-myc expressing cases was 20% in nasal polyps from topical steroid treated patients, but in untreated patients, the rate of c-fos expressing cases was 80% and the rate of c-myc expressing cases was 85%. There were significant differences between two groups (P < 0.01). The c-fos and c-myc expression was remarkably downregulated in nasal polyps from topical steroid treated patients compared to untreated patients.@*CONCLUSION@#The results show that glucocorticoids may induce cell apoptosis in nasal polyps by depressing the c-fos and c-myc expression.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Estudos de Casos e Controles
/
Pólipos Nasais
/
Proteínas Proto-Oncogênicas c-myc
/
Proteínas Proto-Oncogênicas c-fos
/
Budesonida
/
Usos Terapêuticos
/
Tratamento Farmacológico
/
Glucocorticoides
/
Metabolismo
Tipo de estudo:
Estudo observacional
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Ano de publicação:
2008
Tipo de documento:
Artigo
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