Research of the expression of PTEN in squamous cell carcinoma of larynx by the tissue chip technology / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 1081-1084, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-747582
ABSTRACT
OBJECTIVE@#To evaluate the expression of PTEN in squamous cell carcinoma of larynx and its relationship with factors like pathologic fractionation, clinical TNM stage, and prognosis by the tissue chip technology.@*METHOD@#We studied the expression of PTEN gene and its mRNA on a series of 146 cases of primary laryngeal carcinoma patients, 40 cases of precancerous lesion and 26 cases of vocal fold polyp by tissue chip by, immunohistochemistry and in situ hybridization method. The observed data observed and some relevant clinical dada were statistically analyzed.@*RESULT@#The expression of PTEN in vocal fold polyp was negative, and its positive expression in precancerous lesion and laryngeal carcinoma were 40% and 43.15% respectively by immunohistochemistry, and were 72.50 and 59.59% respectively in situ hybridization. The difference between the expression of PTEN in laryngeal carcinoma and its pathological fraction and prognosis was statistically significant, but was not significant between that and location, clinical stage and LN metastasis. The mRNA expression of PTEN was higher than that of the protein expression in precancerous lesion and cancer tissue.@*CONCLUSION@#The tissue microarray technique required shorter time and less expense, and showed higher consistency in our essays. And the present study suggests PTEN was a prognosis factor of the Laryngeal carcinoma.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Carcinoma de Células Escamosas
/
Neoplasias Laríngeas
/
Procedimentos Analíticos em Microchip
/
PTEN Fosfo-Hidrolase
/
Laringe
/
Metabolismo
/
Estadiamento de Neoplasias
Tipo de estudo:
Estudo prognóstico
Limite:
Adulto
/
Idoso
/
Aged80
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Ano de publicação:
2007
Tipo de documento:
Artigo
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