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Expression of phosphofructokinase 1 protein and it's enzyme activity on nasopharyngeal carcinoma / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery ; (24): 1455-1457, 2015.
Artigo em Chinês | WPRIM | ID: wpr-747828
ABSTRACT
OBJECTIVE@#The aim of this study is to investigate the expression of phosphofructokinase 1 and it's enzyme activity in nasopharyngeal carcinoma biopsy samples.@*METHOD@#Sixty-one biopsy samples were detected, including 41 tissues from patients with nasopharyngeal carcinoma as experimental group and 20 tissues from patients with chronic nasopharyngitis as control group. Phosphofructokinase 1 protein was detected by Western blot and it's enzyme activity was detected.@*RESULT@#It was observed that the expression levels of phosphofructokinase 1 protein and it's enzyme activities in the experimental group were higher than that in the control group (P < 0.01). In the experimental group, the expression levels of phosphofructokinase 1 protein and it's enzyme activities in patients with lymph node metastasis were higher than that in patients without lymph node metastasis (P < 0.01).@*CONCLUSION@#Phosphofructokinase 1 may be a marker in occurrence and metastasis of nasopharyngeal carcinoma.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Biópsia / Carcinoma / Biomarcadores Tumorais / Estudos de Casos e Controles / Neoplasias Nasofaríngeas / Nasofaringite / Fosfofrutoquinase-1 / Carcinoma Nasofaríngeo / Metástase Linfática Tipo de estudo: Estudo observacional Limite: Humanos Idioma: Chinês Revista: Journal of Clinical Otorhinolaryngology Head and Neck Surgery Ano de publicação: 2015 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Biópsia / Carcinoma / Biomarcadores Tumorais / Estudos de Casos e Controles / Neoplasias Nasofaríngeas / Nasofaringite / Fosfofrutoquinase-1 / Carcinoma Nasofaríngeo / Metástase Linfática Tipo de estudo: Estudo observacional Limite: Humanos Idioma: Chinês Revista: Journal of Clinical Otorhinolaryngology Head and Neck Surgery Ano de publicação: 2015 Tipo de documento: Artigo