Study of phosphorylated ERK1/2 on nasal polyps / 临床耳鼻咽喉头颈外科杂志

ABSTRACT

OBJECTIVE@#To study the expression of phosphorylated extracellular regulator kinase (ERK1/2) on nasal polyps.@*METHOD@#The immunohistochemistry and Western-blot were used to study the phosphorylation of ERK1/2 on the normal nasal mucosa and nasal polyps.@*RESULT@#The phosphorylated ERK1/2 was mainly expressed on the hyperplastic epithelium, inflammatory cells, glandular epithelium and endothelium of nasal polyps by immunohistochemistry, which was much stronger on nasal polyps than that of normal mucosa. The expression of phosphorylated ERK1/2 was 4.2 times than that of normal mucosa.@*CONCLUSION@#The study indicated that the phosphorylation of ERK1/2 might play an important role on the occurrence and progression of nasal polyps.