The investigation for the neuropeptides of nasal septum in perennial allergic rhinitis patient / 临床耳鼻咽喉头颈外科杂志

ABSTRACT

OBJECTIVE@#To investigate the expression of neuropeptides in the nasal septum of the perennial allergic rhinitis patients, and the mechanism of the alleviation effect of nasal septum rectification to allergic rhinitis.@*METHOD@#Forty-five patients with deviation of nasal septum (20 with allergic rhinitis and 25 without), who undergone nasal septum rectification in Changhai hospital during Jun to Dec, 2007, were included in this research. The levels of SP, VIP, CGRP of the nasal septum were determined by radioimmunoassay.@*RESULT@#In the normal controls, the SP, VIP and CGRP levels of the nasal septal cartilages were lower than that of the nasal septal bones (P0.05), and the CGRP level of the nasal septal cartilages was higher than that of the nasal septal bones (P0.05). There were no statistical significance between the CGRP levels of the nasal septal cartilages in the two groups (P>0.05), neither did that of the nasal septal bones in the two groups (P>0.05).@*CONCLUSION@#The SP level of the nasal septum in the perennial allergic rhinitis patients was higher than that in the normal controls, which was more obvious in the nasal septal cartilages. The VIP level of the nasal septum in the perennial allergic rhinitis patients was higher than that in the normal controls, which was more obvious in the nasal septal cartilages. There were no statistical significance between the CGRP levels of the nasal septum in the perennial allergic rhinitis patients and the normal controls.