Clinical significance of lymph vessel density marked by D2-40 in laryngeal squamous cell carcinomas / 临床耳鼻咽喉头颈外科杂志

ABSTRACT

OBJECTIVE@#To study the relationship between lymphatic vessel density and clinicopathological features of laryngeal squamous cell carcinoma.@*METHOD@#The lymph vessels, 40 specimens of LSCC and normal mucosa, were quantitated by SABC immunohistochemistry staining with lymphatic endothelial marker oncofetal antigen M2A Monoclonal antibody (D2-40).@*RESULT@#The density of peritumoral D2-40(+) vessels in the LSCC group was higher than that of normal mucosa one (P0.05).@*CONCLUSION@#Tumor lymph vessel mainly means peritumoral lymph vessel. The density of peritumoral lymph vessel marked with D2-40 in laryngeal carcinoma tissues was significantly correlated with progression and invasion of tumor.