Expression and significance of TGF-beta1 and HSP70 in human laryngeal squamous cell carcinoma / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 531-534, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-748381
ABSTRACT
OBJECTIVE@#To investigate the expression of TGF-beta1 and HSP70 in human laryngeal squamous cell carcinoma.@*METHOD@#The expression levels of TGF-beta1 and HSP70 in 53 specimens of human laryngeal squamous cell carcinoma and 48 specimens of para-carcinoma were detected by immuno- histochemistry and computer assisted image analysis.@*RESULT@#The expression of TGF-beta1 was decreased in carcinoma tissues compared with para-carcinoma tissues ( P < 0.05), while the expression of HSP70 was increased ( P < 0.05). Both the expression of TGF-beta1 and HSP70 were significantly correlated with the differentiation of laryngeal squamous cell carcinoma (P < 0.01 or P < 0.05). However, there was a negative correlation between TGF-beta1 and HSP70 (r = -0.87, P < 0.01).@*CONCLUSION@#TGF-beta1 and HSP70 play an important role in malignant behaviors of human laryngeal carcinoma.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Prognóstico
/
Imuno-Histoquímica
/
Carcinoma de Células Escamosas
/
Neoplasias Laríngeas
/
Proteínas de Choque Térmico HSP70
/
Fator de Crescimento Transformador beta1
/
Metabolismo
/
Estadiamento de Neoplasias
Tipo de estudo:
Estudo prognóstico
Limite:
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Ano de publicação:
2007
Tipo de documento:
Artigo
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