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Latent membrane protein-1 of EB virus and the phenotype of epithelial-mesenchymal transition and cervical lymph node metastasis in nasopharyngeal carcinoma / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery ; (24): 270-273, 2011.
Artigo em Chinês | WPRIM | ID: wpr-748483
ABSTRACT
OBJECTIVE@#To evaluate the relation of EB virus latent membrane protein-1 (LMP-1) and the phenotype of epithelial-mesenchymal transition (EMT) and cervical lymph node metastasis in nasopharyngeal carcinoma.@*METHOD@#Based on histopathology and MRI imaging, nasopharyngeal biopsy tissues from 88 patients with nasopharyngeal carcinoma were divided into 3 groups pathologic metastasis (18), MRI metastasis(40) and without metastasis (30). The expressions of LMP-1, STAT3, Twist, E-Cadherin and Vimentin were examined immunohistochemically in biopsy tissues.@*RESULT@#LMP-1 expression was found in 35 of 88 biopsy tissues with a positive rate of 38.7%. The positive rates of LMP-1 in groups of pathologic metastasis, MRI metastasis and without metastasis were 38.9% (7/18), 47.5% (19/40) and 30.0% (9/30), respectively, and significant difference were not found among three groups. The expression of LMP-1 was positively correlated to both expressions of Twist and Vimentin (r = 0.276 and 0.282, are P < 0.01), but not to both expressions of STAT3 and E-Cadherin. The positive expressions or abnormal expression of STAT3, Twist, Vimentin and E-Cadherin were found in 57 of 88 (64.8%), 48 of 88 (54.5%), 22 of 88 (20.0%)and 53 of 88 (60.2%), respectively. Significant differences in the expression of STAT3, Twist, Vimentin and E-Cadherin were all found among groups of pathologic metastasis, MRI metastasis and without metastasis, respectively (are P < 0.05). The expression of STAT3 was positively correlated to both expressions of Twist and Vimentin (r = 0.712 and 0.316, P < 0.01).@*CONCLUSION@#EMT plays important role in cervical lymph node metastasis in nasopharyngeal carcinoma. LMP-1 may be only as one of upstream factors associated with the EMT, but not the decisive factor for cervical lymph node metastasis.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Vimentina / Virologia / Proteínas Nucleares / Caderinas / Proteínas da Matriz Viral / Neoplasias Nasofaríngeas / Herpesvirus Humano 4 / Fator de Transcrição STAT3 / Proteína 1 Relacionada a Twist Limite: Adulto / Idoso / Aged80 / Feminino / Humanos / Masculino Idioma: Chinês Revista: Journal of Clinical Otorhinolaryngology Head and Neck Surgery Ano de publicação: 2011 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Vimentina / Virologia / Proteínas Nucleares / Caderinas / Proteínas da Matriz Viral / Neoplasias Nasofaríngeas / Herpesvirus Humano 4 / Fator de Transcrição STAT3 / Proteína 1 Relacionada a Twist Limite: Adulto / Idoso / Aged80 / Feminino / Humanos / Masculino Idioma: Chinês Revista: Journal of Clinical Otorhinolaryngology Head and Neck Surgery Ano de publicação: 2011 Tipo de documento: Artigo