A Case of 5-Fluorouracil Induced Encephalopathy / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
;
: 118-120, 2010.
Artigo
em Inglês
| WPRIM
| ID: wpr-74856
ABSTRACT
Patients with reduced dihydropyrimidine dehydrogenase (DPD) activity are at risk for experiencing serious adverse effects following 5-fluorouracil (5-FU) based chemotherapy. Neurotoxicity is considered an extremely rare side effect of 5-FU. We report here on an unusual case of 5-FU induced encephalopathy. A 38-year-old woman with advanced gastric carcinoma was treated with adjuvant chemotherapy that consisted of infused 5-FU (1,000 mg/m2) for 5 days and cisplatin (60 mg/m2) on day 1 following total gastrectomy. Nineteen days after starting chemotherapy, the patient displayed a sudden onset of slurred speech, confusion, cognitive disturbances and paranoia. A magnetic resonance image (MRI) of the brain showed no structural abnormalities, and the other laboratory tests provided no explanations for her symptoms, other than a slightly elevated ammonia level. The patient was treated with a lactulose retention enema and thiamine infusion, the 5-FU was halted and her symptoms then recovered after 7 days.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Transtornos Paranoides
/
Retenção Psicológica
/
Tiamina
/
Encéfalo
/
Espectroscopia de Ressonância Magnética
/
Cisplatino
/
Quimioterapia Adjuvante
/
Di-Hidrouracila Desidrogenase (NADP)
/
Enema
/
Fluoruracila
Limite:
Adulto
/
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Cancer Research and Treatment
Ano de publicação:
2010
Tipo de documento:
Artigo
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