Expression of group I mGluRs in rat flocculus after unilateral labyrinthectomy / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 604-606, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-748681
ABSTRACT
OBJECTIVE@#Studies revealed that cerebellar flocculus-paraflocculus complex plays an important in vestibular compensation. To observe the expression change of Group I mGluRs in flocculus following left unilateral labyrinthectomy (UL).@*METHOD@#After setting left labyrinthectomy, the change of Group I mGluRs was detected by RT-PCR.@*RESULT@#Group I mGluR5 was induced increase in both side flocculus after unilateral labyrinthectomy. By contrast, mGluR1 was induced decrease. However, that of the lesioned side was stronger than that of the unlesioned side.@*CONCLUSION@#UL can induce change of Group I mGluRs in the flocculus. The fall in the resting discharge of the primary vestibular afferents and/or in the deafferented central vestibular neurons may cause the change of mGluRs. But the significance of the change of mGluRs in the vestibular compensation is still unknown.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Núcleos Vestibulares
/
Núcleos Cerebelares
/
Vestíbulo do Labirinto
/
Ratos Wistar
/
Receptores de Glutamato Metabotrópico
/
Receptor de Glutamato Metabotrópico 5
/
Metabolismo
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Ano de publicação:
2009
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS