Expression and significance of VCAM-1 in subjects with allergic inflammation of respiratory tract / 临床耳鼻咽喉头颈外科杂志

ABSTRACT

OBJECTIVE@#To study the expression and significance of vascular cell adhesion molecule-1 (VCAM-1) in subjects with allergic inflammation of respiratory tract.@*METHOD@#Thirty-nine subjects with allergic rhinitis and asthma (allergic rhinitis and asthma group) and twenty-one subjects with only allergic rhinitis (allergic rhinitis group) were divided into two group. Bronchial and nasal biopsy specimens were taken and were stained with HE. The expression of VCAM-1 in nasal and bronchial mucosa was detected by immunohistochemistry technique.@*RESULT@#The amounts of eosinophils within bronchial mucosa of allergic rhinitis and asthma group were significantly higher than that of allergic rhinitis group (t=12.81, P<0.01). The difference of VCAM-1 expression between allergic rhinitis group and allergic rhinitis and asthma group was not statistically significant . The amounts of VCAM-1 positive cell in bronchial mucosa of allergic rhinitis and asthma group were significantly higher than that of allergic rhinitis group (t=9.43, P<0.01). The number of VCAM-1 positive cells in bronchial mucosa was significantly positively correlated with the number of eosinophils in bronchial mucosa of allergic rhinitis and asthma group (r=0.783, P<0.01).@*CONCLUSION@#This study shows that upregulation of VCAM results in generalized airway inflammation in patients with allergic rhinitis.