Study on influential factors associated with the long-term effect of allergic rhinitis specific immunotherapy / 临床耳鼻咽喉头颈外科杂志

ABSTRACT

OBJECTIVE@#To investigate the influential factors associated with the long-term effect of allergic rhinitis (AR) specific immunotherapy (SIT).@*METHOD@#Retrospective analyzed the following visual analog scale(VAS) before and after the specific immunotherapy of 219 patients with allergic rhinitis. Logistic regression and pair t-test were used to explore the key factors influencing the prognosis.@*RESULT@#(1) The gender and the VAS before specific immunotherapy (P 0.05) were not associated with the long-term effect of specific immunotherapy; (2) Compared VAS of different endpoints with VAS before the treatment,there were significant differences. The primary endpoints were the time following no more than half a year (total effective rate 50.0%), half a year to 1 year (total effective rate 51.7%), 1 to 2 year (total effective rate 47.1%), 2 to 3 year (total effective rate 54.5%) and over 3 year (total effective rate 40.7%).@*CONCLUSION@#Apart from the gender and the VAS before specific immunotherapy,genetic and other factors can not significant influence the long-term effect of specific immunotherapy. The effect of specific im- munotherapy seems to last for 3 years at least. Increasing stitches can not improve long-term effect of SIT,but it can consolidate the effect. The long-term effect of specific immunotherapy tends to drop off with fluctuations over time and the higher of VAS before SIT,the better effect of long-term SIT. Further more, the long-term effect of SIT of male is worse than female. In consequences, we speculate epigenetics related to the interaction between environmental factors and genetic factors plays an important role in the long-term effect of allergic rhinitis specific immunotherapy.