Expression of CDK4 and p16 in laryngeal squamous cell carcinoma / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 108-110, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-748770
ABSTRACT
OBJECTIVE@#To investigate the expression of CDK4 and p16 in laryngeal squamous cell carcinoma (LSCC) tissues.@*METHOD@#The expressions of CDK4 and p16 in 30 cases of LSCC tissues and 20 cases of edge tissues were detected by immunohistochemical technology SP method, and discuss their correlation with clincial pathology and clinical stage of LSCC.@*RESULT@#The positive rates of CDK4 and p16 were 63. 3 %,46. 7% in LSCC tissues, and the positive rates were 25%, 90% in edge tissues. The expression of CDK4 in LSCC tissues was significantly higher than that in edge tissues(P 0. 05); The expression of p16 in LSCC tissues was significantly lower than that in edge tissues(P0. 05) ;there is a negative correlation between CDK4 and p16 (r= -0. 786, P<0. 05).@*CONCLUSION@#Low expression of p16 and high expression of CDK4 may play an important role in the development of LSCC and the low expression of p16 in LSCC tissue could be used as important reference markers of malignant degree of tumour.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Prognóstico
/
Carcinoma de Células Escamosas
/
Biomarcadores Tumorais
/
Neoplasias Laríngeas
/
Inibidor p16 de Quinase Dependente de Ciclina
/
Quinase 4 Dependente de Ciclina
/
Carcinoma de Células Escamosas de Cabeça e Pescoço
/
Neoplasias de Cabeça e Pescoço
/
Metabolismo
Tipo de estudo:
Estudo prognóstico
Idioma:
Chinês
Revista:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Ano de publicação:
2015
Tipo de documento:
Artigo
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