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The expression of neuN in the development of olfactory bulb and epithelium of mice / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery ; (24): 363-365, 2007.
Artigo em Chinês | WPRIM | ID: wpr-748815
ABSTRACT
OBJECTIVE@#To study the expression characteristics of NeuN (neuron-specific nuclear protein/neuronal nuclei) in the development of mice olfactory bulb and epithelium.@*METHOD@#The expression of NeuN in the heads of E9.5, E11.5, E14.5, E17.5, newborn and adult mice were examined by immunofluorescence method.@*RESULT@#NeuN was expressed in mature neural cells at the margin area of olfactory bulb of new natal mice while the layers of olfactory bulb could not be distinguished. Mature neural cells expressing NeuN aggregated in the granule cells layer, when layers of olfactory bulb of adult mice were clearly formed. The expression of NeuN could not be observed in bipolar olfactory receptor neurons (ORN) in olfactory epithelium.@*CONCLUSION@#It is usually believed that NeuN is expressed in most mature neurons. However, during the development of olfactory bulb and epithelium, NeuN is expressed only in mature neural cells migrating from margin area to the inner granule cells layer of olfactory bulb. It is proposed that the migration of granule cells in olfactory bulb might be related to the formation of smell pattern.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Bulbo Olfatório / Proteínas Nucleares / Mucosa Olfatória / Embriologia / Animais Recém-Nascidos / Metabolismo / Proteínas do Tecido Nervoso / Neurônios Limite: Animais / Gravidez Idioma: Chinês Revista: Journal of Clinical Otorhinolaryngology Head and Neck Surgery Ano de publicação: 2007 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Bulbo Olfatório / Proteínas Nucleares / Mucosa Olfatória / Embriologia / Animais Recém-Nascidos / Metabolismo / Proteínas do Tecido Nervoso / Neurônios Limite: Animais / Gravidez Idioma: Chinês Revista: Journal of Clinical Otorhinolaryngology Head and Neck Surgery Ano de publicação: 2007 Tipo de documento: Artigo