Expression of glucose-regulated protein 78 in human laryngeal squamous cell carcinoma and its clinical significance / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 815-817, 2013.
Artigo
em Chinês
| WPRIM
| ID: wpr-749241
ABSTRACT
OBJECTIVE@#To investigate the expression of glucose-regulated protein78 (GRP78) in human laryngeal squamous cell carcinoma,and to evaluate its role in the development progress of human laryngeal squamous cell carcinoma.@*METHOD@#The expressions of GRP78 in human laryngeal squamous cell carcinoma, matched pair pericarcinomatous tissue and normal laryngeal squamous epithelial tissue from 90 patients were detected using immunohistochemistry analysis. In addition, the relationship between GRP78 expression and clinical parameters of patients, such as gender, tumor differentiation grade stage, and lymphatic metastasis was analyzed.@*RESULT@#The positive ratio of GRP78 expression in LSCC, matched pair pericarcinomatous tissue and normal laryngeal squamous epithelial tissue were 86.67%, 32.22% and 8.89%. The GRP78 expressions in different tissues were significantly different (P 0.05).@*CONCLUSION@#The expression level of GRP78 protein in human laryngeal squamous cell carcinoma is high and its expression is positively associated with the malignancy of carcinoma. The expression of GRP78 protein participates in the development progress of human laryngeal squamous cell carcinoma.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Prognóstico
/
Imuno-Histoquímica
/
Carcinoma de Células Escamosas
/
Neoplasias Laríngeas
/
Carcinoma de Células Escamosas de Cabeça e Pescoço
/
Neoplasias de Cabeça e Pescoço
/
Proteínas de Choque Térmico
/
Linfonodos
/
Metabolismo
Tipo de estudo:
Estudo prognóstico
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Ano de publicação:
2013
Tipo de documento:
Artigo
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