Study on laryngeal cancer related on polymorphism of the Arg399Gln of XRCC1 DNA repair gene in different nationalities in Xinjiang / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 948-954, 2013.
Artigo
em Chinês
| WPRIM
| ID: wpr-749256
ABSTRACT
OBJECTIVE@#To study genetic polymorphism of XRCC1 Arg399Gln and the laryngeal cancer risk.@*METHOD@#A case-control study was performed on 60 patients with laryngeal squamous cell carcinoma and 120 random healthy control group. The two groups were matched by sex and age. Multiplex SNaPshot technic was used to explore polymorphism of DNA repair gene XRCC1 Arg399Gln in distribution of patient with laryngeal squamous cell carcinoma and normal control.@*RESULT@#The frequency of XRCC1c. 399Arg/Gln+Gln/Gln genotypes in the case group was higher than that in the control group (P Gln might lead to a increased risk of laryngeal cancer.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Etnicidade
/
Estudos de Casos e Controles
/
China
/
Neoplasias Laríngeas
/
Epidemiologia
/
Polimorfismo de Nucleotídeo Único
/
Proteínas de Ligação a DNA
/
Reparo do DNA
/
Proteína 1 Complementadora Cruzada de Reparo de Raio-X
/
Genética
Tipo de estudo:
Estudo observacional
/
Fatores de risco
Limite:
Idoso
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
Ásia
Idioma:
Chinês
Revista:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Ano de publicação:
2013
Tipo de documento:
Artigo
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