Expression and significance of gene Rad52 in nasopharyngeal carcinoma / 临床耳鼻咽喉头颈外科杂志

ABSTRACT

OBJECTIVE@#To investigate the expression and clinical significance of Rad52, a homologous recombination repair gene, in tissues of nasopharyngeal carcinoma (NPC).@*METHOD@#The expression of Rad52 was detected with three-step immunohistochemistry technique in tissues of 38 NPC patients and which have the corresponding paracancerous tissues. All of the Rad52 expression and clinical data (gender, age, clinical stage ) were compared and analyzed to conclude the relationship between them.@*RESULT@#The Rad52 expressions were significantly different from NPC tissues to peri-NPC tissues (P 0.05). The expression of Rad52 influenced the survival time of NPC patients significantly (P < 0.05).@*CONCLUSION@#The Rad52 expression can be a useful prognostic and treatment factor for NPC patients.