Mitochondrial mechanisms of antisense oligodeoxynucleotide Stat3 induced apoptosis in laryngeal carcinoma cell / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 316-318, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-749406
ABSTRACT
OBJECTIVE@#To investigate the changes of mitochondrion by transferring antisense oligodeoxynucleotide Stat3 into laryngeal carcinoma Hep-2 cell, for elucidating the mechanism of laryngeal carcinoma Hep-2 cell apoptosis, for developing more effective treatment for laryngeal cancer.@*METHOD@#The designed Stat3 ASODN was transferred into laryngeal carcinoma Hep-2 cell by lipofection. Mitochondrion membrane potential, VDAC and Cyt-c were detected for determining the changes of mitochondrion.@*RESULT@#MMP was fell, Cyt-c and VDAC were increased with the heighten concentration of ASODN.@*CONCLUSION@#Mitochondria approach play an important role in the apoptosis mechanism of human Hep-2 cell by Stat3. This research elucidated the regulating mechanism of Hep-2 cell proliferation by Stat3, provided a new research focus for clinical therapy.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Transfecção
/
Neoplasias Laríngeas
/
Apoptose
/
Oligodesoxirribonucleotídeos Antissenso
/
Citocromos c
/
Proliferação de Células
/
Fator de Transcrição STAT3
/
Canais de Ânion Dependentes de Voltagem
/
Potencial da Membrana Mitocondrial
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Ano de publicação:
2012
Tipo de documento:
Artigo
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