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The association between genetic polymorphisms of IL-6 and the susceptibility of chronic rhinosinusitis / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery ; (24): 197-204, 2012.
Artigo em Chinês | WPRIM | ID: wpr-749453
ABSTRACT
OBJECTIVE@#To investigate the relationship between the promoter polymorphism of IL6 (-174G > C, -572G > C and -597G > A) and chronic rhinosinusitis (CRS).@*METHOD@#The case-control study consisted of 123 patients with CRS and 239 controls from a Chinese Han population from Shanghai. The genotypes of the subjects were determined by polymerase chain reaction-restriction fragment length polymorphism and gene sequencing. Besides, the concentrations of the totle immunoglobulin E (TIgE) and eosinophilic cationic protein (ECP) in the blood were also determined.@*RESULT@#The -174G > C and -597G > A polymorphisms were not detected in this study population. Significant differences in genotype and allele frequencies of -572C/G were observed between CRS patients and control groups. In CRS patients, the CC, CG, GG genotype frequencies were 69.1%, 29.3%, 1.6%, C, G allele frequencies were 83.7%, 16.3%. In control group, the genotype frequencies were 55.2%, 42.3%, 2.5%, the allele frequencies were 76.4%, 23.6%, respectively. The -572CC genotype was associated with an increased risk of developing CRS (P C polymorphism is associated with the susceptibility to CRS. CC genotype could be an independent risk factor.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Sinusite / Estudos de Casos e Controles / China / Doença Crônica / Fatores de Risco / Interleucina-6 / Predisposição Genética para Doença / Polimorfismo de Nucleotídeo Único / Frequência do Gene / Genética Tipo de estudo: Estudo de etiologia / Estudo observacional / Fatores de risco Limite: Adolescente / Adulto / Idoso / Aged80 / Feminino / Humanos / Masculino País/Região como assunto: Ásia Idioma: Chinês Revista: Journal of Clinical Otorhinolaryngology Head and Neck Surgery Ano de publicação: 2012 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Sinusite / Estudos de Casos e Controles / China / Doença Crônica / Fatores de Risco / Interleucina-6 / Predisposição Genética para Doença / Polimorfismo de Nucleotídeo Único / Frequência do Gene / Genética Tipo de estudo: Estudo de etiologia / Estudo observacional / Fatores de risco Limite: Adolescente / Adulto / Idoso / Aged80 / Feminino / Humanos / Masculino País/Região como assunto: Ásia Idioma: Chinês Revista: Journal of Clinical Otorhinolaryngology Head and Neck Surgery Ano de publicação: 2012 Tipo de documento: Artigo