Role of TGF-beta, IL-10 and IL-17 in allergic rhinitis patients with specific immunotherapy / 临床耳鼻咽喉头颈外科杂志

ABSTRACT

OBJECTIVE@#To detect the level of TGF-beta, IL-10 and IL-17 in the allergic rhinitis(AR) patients pre- and post-specific immunotherapy (SIT).@*METHOD@#The level of TGF-beta, IL-10 and IL-17 in serum of 48 AR patients were detected by enzyme-linked immunosorbent assay before SIT. and the nasal symptom score (NSS) was evaluated in the first and second year after SIT. At the same time. 35 healthy persons were made as normal.@*RESULT@#(1) The level of TGF-beta and IL-10 in serum of AR patients were lower than that of normal group (P 0.05) when SIT was taken for one year.@*CONCLUSION@#IL-10 and TGF-beta were fluctuated in AR patients taking SIT, which raised first and then dropped. but the level of IL-10 and TGF-beta was higher than that of pre- immunotherapy. However, the level of IL-17 continuously declined in the whole process. It showed that the level change of IL-10, TGF-beta and IL-17 correlate with patients' symptom only two years after SIT,so the level change of IL-10, TGF-beta and IL-17 can be used as an index for evaluating the treatment effectiveness of SIT at that time.