Serum gamma-glutamyl transferase activity has no prognostic value in patients with acute myocardial infarction / 대한내과학회지
Korean Journal of Medicine
;
: 281-289, 2007.
Artigo
em Coreano
| WPRIM
| ID: wpr-74959
ABSTRACT
BACKGROUND:
Serum gamma-glutamyl transferase activity (GGT) is able to catalyse low-density lipoprotein oxidation in coronary atherosclerotic plaques and has a role in the pathogenesis of atherosclerosis. GGT has been shown to be an independent risk factor for cardiac mortality in patients with a previous myocardial infarction. The purpose of this study is to determine the prognostic value of GGT within its normal range at an acute stage in patients with acute myocardial infarction.METHODS:
In a retrospective study, GGT and other cardiac risk factors were evaluated in 192 patients (M/F=143/49; mean age 60.8+/-11.8 years) who were diagnosed with an acute myocardial infarction at the emergency room. We compared the serum GGT values for each patient with or without a cardiac event, including cardiac death, non-fetal myocardial infarction and unstable angina, after an acute myocardial infarction for a mean follow-up of 16.5+/-10.8 months.RESULTS:
During the follow-up period, 17 patients underwent cardiac death and experienced an acute myocardial infarction and 23 patients had unstable angina. Although the mean GGT values were significantly different from patients with cardiac events (29.5+/-10.0 U/L vs 25.0+/-11.2 U/L, p=0.024), serum GGT was not an independent cardiac risk factor for a cardiac event based on multivariate analysis adjusted for age, sex, alcohol and known cardiovascular risk factors.CONCLUSIONS:
Serum GGT within its normal range at an acute stage in patients that experienced an acute myocardial infarction is not an independent prognostic marker.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Valores de Referência
/
Transferases
/
Análise Multivariada
/
Estudos Retrospectivos
/
Fatores de Risco
/
Seguimentos
/
Mortalidade
/
Morte
/
Serviço Hospitalar de Emergência
/
Aterosclerose
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Medicine
Ano de publicação:
2007
Tipo de documento:
Artigo
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