Lamotrigine-induced toxic epidermal necrolysis confirmed by in vitro granulysin and cytokine assays
Asia Pacific Allergy
;
(4): 253-256, 2014.
Artigo
em Inglês
| WPRIM
| ID: wpr-749999
ABSTRACT
Lamotrigine is a recent medication which is prescribed for various neuropsychiatric conditions. It is generally well-tolerated, but recent pharmacoepidemiological evidence suggests that lamotrigine is associated with risks of developing severe cutaneous drug reactions like toxic epidermal necrolysis (TEN). However, there still remains the diagnostic challenge regarding how to confirm the drug causality in suspected cases. In most cases so far, lamotrigine causality has not been objectively demonstrated, which was possibly due to high risk of oral challenge tests or the lack of useful in vitro drug assays. Here we report a case of lamotrigine-induced TEN, of which the drug causality was confirmed by in vitro granulysin and cytokine assays.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Técnicas In Vitro
/
Células Matadoras Naturais
/
Síndrome de Stevens-Johnson
/
Ciclosporina
Idioma:
Inglês
Revista:
Asia Pacific Allergy
Ano de publicação:
2014
Tipo de documento:
Artigo
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