The impact of sinusitis on the long-term clinical outcomes of asthma
Asia Pacific Allergy
;
(4): 222-229, 2014.
Artigo
em Inglês
| WPRIM
| ID: wpr-750002
ABSTRACT
BACKGROUND:
Upper respiratory diseases have been linked with lower respiratory diseases. However, the long-term effect of sinusitis on the clinical outcomes of asthma has not been fully evaluated.OBJECTIVE:
The aim of this study was to investigate the impact of sinusitis on the disease progression of asthma.METHODS:
Seventy-five asthmatic patients confirmed with the methacholine bronchial provocation test or bronchodilator response were included. The study patients underwent paranasal sinus x-ray upon their asthma evaluation and they visited the hospital at least 3 years or longer. We retrospectively reviewed their medical records and compared data according to the presence of comorbid sinusitis.RESULTS:
Among the 75 asthmatic subjects, 38 subjects (50.7%) had radiologic evidence of sinusitis. Asthmatics with sinusitis had significantly lower forced expiratory volume in 1 second (FEV₁; 79.2% vs. 88.2%) and PC20 values (5.2 mg/mL vs. 8.9 mg/mL) compared to asthmatics without sinusitis at the time of diagnosis. This difference in FEV₁ disappeared (82.6% vs. 87.2%) in the 3-year follow-up, although FEV₁ was more variable (31.7% vs. 23.5%) and worst FEV₁ was also significantly lower in patients with sinusitis compared to those without (70.9% vs. 79.0%). There were no significant differences in the number of hospital visits, acute exacerbations, and scores for the asthma control test.CONCLUSION:
Although sinusitis was associated with lower baseline lung function and higher hyperreactivity, sinusitis was not related with significant deterioration in lung function over 3 years of follow-up. Asthmatics with sinusitis showed more variability in lung function during the follow-up period. Healthcare utilization was not different except antibiotics use.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Asma
/
Sinusite
/
Testes de Provocação Brônquica
/
Volume Expiratório Forçado
/
Prontuários Médicos
/
Estudos Retrospectivos
/
Seguimentos
/
Cloreto de Metacolina
/
Progressão da Doença
/
Atenção à Saúde
Tipo de estudo:
Estudo diagnóstico
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Humanos
Idioma:
Inglês
Revista:
Asia Pacific Allergy
Ano de publicação:
2014
Tipo de documento:
Artigo
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