Repeat oral food challenges in peanut and tree nut allergic children with a history of mild/moderate reactions
Asia Pacific Allergy
;
(4): 170-176, 2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-750030
ABSTRACT
BACKGROUND:
In peanut and tree nut allergic children a history of anaphylaxis is associated with subsequent severe reactions.OBJECTIVE:
We aimed to prospectively rechallenge peanut and tree nut allergic children with a history of mild/moderate reactions to assess their allergy over time.METHODS:
In this cohort study peanut and tree nut allergic children with a history of mild/moderate reactions during a controlled oral challenge were invited to have a follow-up oral challenge to the same food at least 1 year later.RESULTS:
Twenty-six children participated in the study. The mean time interval between the first and second challenge for all participants was 35.5 months. Peanut or tree nut allergy resolved in 38.5% of participants. Those with persistent peanut or tree nut allergy showed a decrease in their reaction threshold and/or increased severity in 81% of cases. There were no demographic features or skin test results that were predictive of changes in severity over time.CONCLUSION:
Peanut and tree nut allergic children with a history of mild/moderate reactions who remained allergic demonstrated a high rate of more severe reactions and/or reduced thresholds upon rechallenge over a year later, however, the rate of resolution of allergy in this group may be higher than previously reported.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Arachis
/
Árvores
/
Testes Cutâneos
/
Estudos Prospectivos
/
Estudos de Coortes
/
Seguimentos
/
Hipersensibilidade a Noz
/
Hipersensibilidade a Amendoim
/
Hipersensibilidade
/
Anafilaxia
Tipo de estudo:
Estudo de etiologia
/
Estudo de incidência
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Criança
/
Humanos
Idioma:
Inglês
Revista:
Asia Pacific Allergy
Ano de publicação:
2015
Tipo de documento:
Artigo
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