Successful cholecalciferol desensitisation in a case of delayed hypersensitivity
Asia Pacific Allergy
;
(4): e14-2019.
Artigo
em Inglês
| WPRIM
| ID: wpr-750179
ABSTRACT
Hypersensitivity to cholecalciferol (vitamin D3) or its active metabolite, calcitriol, is an exceedingly rare clinical phenomenon, with only 2 previously reported cases of suspected immediate hypersensitivity. Diagnosis of delayed drug hypersensitivity reactions is inherently difficult due to the lack of any robust in vitro diagnostic assay, particularly in those patients for whom provocation testing confers an unacceptable risk. In these situations, diagnosis relies on reproducible clinical manifestations following administration of the culprit agent, resolution upon its withdrawal and exclusion of other potential differential diagnoses. Based on these criteria, we propose the first reported case of delayed hypersensitivity to cholecalciferol successfully managed with a desensitisation protocol to pure cholecalciferol.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Técnicas In Vitro
/
Calcitriol
/
Colecalciferol
/
Diagnóstico
/
Diagnóstico Diferencial
/
Hipersensibilidade a Drogas
/
Hipersensibilidade
/
Hipersensibilidade Tardia
/
Hipersensibilidade Imediata
Tipo de estudo:
Estudo diagnóstico
/
Guia de Prática Clínica
Limite:
Humanos
Idioma:
Inglês
Revista:
Asia Pacific Allergy
Ano de publicação:
2019
Tipo de documento:
Artigo
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