Association of IL-1 gene polymorphisms with chronic rhinosinusitis with and without nasal polyp
Asia Pacific Allergy
;
(4): e22-2019.
Artigo
em Inglês
| WPRIM
| ID: wpr-750189
ABSTRACT
BACKGROUND:
Chronic rhinosinusitis (CRS) is one of the most common and complex chronic inflammatory disease of sinonasal mucosa. Even though the pathogenesis of CRS is multifactorial and still unclear, the role of cytokines especially interleukin-1 (IL-1) is being investigated worldwide in different population because of varying results obtained.OBJECTIVE:
To study the association of IL-1 (A and B) gene polymorphisms with chronic rhinosinusitis with nasal polyp (CRSwNP) and without nasal polyp (CRSsNP), and other factors related.METHODS:
This is a case-controlled study which include a total of 138 subjects recruited from Otorhinolaryngology-Head and Neck Surgery clinic in Hospital Universiti Sains Malaysia. Genotyping of the IL-1A (+4845G, +4845T) and IL-1B (−511C, −511T) were performed with restriction fragment length polymorphism analysis.RESULTS:
There was a statistical significant association between IL-1B (−511C, −511T) polymorphism with CRSwNP and CRSsNP (p 0.95, and 0.254, respectively).CONCLUSION:
This study indicates an association of IL-1B (−511C, −511T) polymorphism with CRSwNP and CRSsNP in our population, hence there is a possibility of IL-1B involvement in modulating pathogenesis of CRS. There was no significant association of IL-1A (+4845G, +4845T) polymorphism with CRSwNP and CRSsNP, and other factors related.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Asma
/
Polimorfismo de Fragmento de Restrição
/
Estudos de Casos e Controles
/
Aspirina
/
Pólipos Nasais
/
Citocinas
/
Interleucina-1
/
Polimorfismo de Nucleotídeo Único
/
Genótipo
/
Hipersensibilidade
Tipo de estudo:
Estudo observacional
/
Fatores de risco
Limite:
Humanos
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Asia Pacific Allergy
Ano de publicação:
2019
Tipo de documento:
Artigo
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