Human leukocyte antigen-associated severe cutaneous adverse drug reactions: from bedside to bench and beyond
Asia Pacific Allergy
;
(4): e20-2019.
Artigo
em Inglês
| WPRIM
| ID: wpr-750191
ABSTRACT
Despite their being uncommon, severe cutaneous adverse drug reactions (SCARs) result in a very great burden of disease. These reactions not only carry with them a high mortality (10%–50%) and high morbidity (60%) with severe ocular complications, alopecia, oral and dental complications and development of autoimmune diseases, but also create a substantial economic burden for patients' families and society. SCARs are, therefore, an important medical problem needing a solution in many countries, especially in Asia. The clinical spectrum of SCARs comprises Stevens-Johnson syndrome, toxic epidermal necrolysis, DRESS (drug rash with eosinophilia and systemic symptoms) (also known as drug hypersensitivity syndrome or drug-induced hypersensitivity syndrome) and acute generalised exanthematous pustulosis. Recent crucial advances in determining genetic susceptibility and understanding how T cells recognise certain medications or their metabolites via the major histocompatibility complex and the effects of cofactors, have led to the implementation of cost-effective screening programs enabling prevention in a number of countries, and to further understanding of the patho-mechanisms involved in SCARs and their significance. In this review, we document comprehensively the journey of SCARs from bedside to bench and outline future perspectives in SCARs research.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Ásia
/
Doenças Autoimunes
/
Linfócitos T
/
Programas de Rastreamento
/
Mortalidade
/
Cicatriz
/
Síndrome de Stevens-Johnson
/
Predisposição Genética para Doença
/
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
/
Eosinofilia
Tipo de estudo:
Estudo prognóstico
/
Estudo de rastreamento
Limite:
Humanos
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Asia Pacific Allergy
Ano de publicação:
2019
Tipo de documento:
Artigo
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