Clinical value of serum amyloid A detection in the diagnosis of infective endophthalmitis / 国际眼科杂志(Guoji Yanke Zazhi)

ABSTRACT

@#AIM:To investigate the clinical value of serum amyloid A(SAA)in the diagnosis of infectious endophthalmitis. <p>METHODS:A total of 270 patients admitted to the Eye Hospital of Wenzhou Medical University from June 2016 to March 2019 were collected, including 116 patients with infectious endophthalmitis as the experimental group and 154 non-infectious patients as the control group. The levels of SAA was detected by colloidal gold immunochromatography. Variables were compared and diagnostic value was measured by using receiver operating characteristic(ROC)curve.<p>RESULTS:The median levels of SAA in experimental group and control group were 14.98mg/L and 2.56mg/L, respectively,the difference between the two groups was statistically significant(<i>P</i><0.001); the median levels of CRP and WBC had statistic difference between two groups, respectively(<i>P</i><0.001). The area under the ROC curve of SAA, CRP and WBC for diagnosis of infectious endophthalmitis were 0.772, 0.638 and 0.618 respectively. The optimal cut-off value corresponding to the maximum value of Youden index was 6.975mg/L by SAA, the sensitivity was 63.79% and the specificity was 84.42%.<p>CONCLUSION: SAA combined with CRP and WBC can improve the diagnostic efficacy of infective endophthalmitis. SAA can provide useful reference information for the assistant diagnosis of infectious endophthalmitis, which is worthy of clinical application.