Progresses of the characteristics of pulmonary hypertension and surgical treatment in children with Down syndrome and congenital heart disease / 国际儿科学杂志

ABSTRACT

Down's syndrome, also known as trisomy 21, is most associated with congenital heart dis-ease, and pulmonary hypertension can be formed early due to factors such as cardiovascular shunt, upper air-way obstruction, and lung tissue dysplasia. it is characteristed by early occurrence, rapid progress, heavy de-gree and poor recovery, active intervention and early surgical treatment are important for improving the progno-sis of children with Down syndrome. This paper reviews the progress of Down's syndrome with congenital heart disease, the characteristics of pulmonary hypertension and the possible pathogenesis, surgical timing and prog-nosis.