Clinical application of exosomal miRNA as biomarker in breast cancer / 国际肿瘤学杂志

ABSTRACT

MicroRNA (miRNA)has a tumor-specific expression profile and plays an important role in the occurrence and progression of tumors. It is protected from RNase in body fluids through the inclusion of exo-somes and translocates genetic information horizontally between breast cancer cells. Recent studies on exosome miRNA have found that it is closely related to the occurrence,diagnosis,treatment and prognosis of breast cancer. The in-depth study in this field can provide theoretical basis for the clinical application of exosome miRNA as a biomarker for breast cancer.