Clinical Significance of Serum Vitamin D Levels Change in Patients with Breast Cancer before and after Chemoradiotherapy / 昆明医科大学学报

ABSTRACT

Objective To investigate the clinical significance of serum vitamin D levels change in patients with breast cancer (BC) before and after radiotherapy and chemotherapy.Methods A total of 100 BC patients and 100 healthy controls were enrolled in the First Affiliated Hospital of Xi'an Jiaotong University from June 2016 to June 2017. All the patients received adjuvant chemotherapy and radiotherapy after operation. Serum 25-hydroxyvitamin D3 (25-OHD) levels were measured using the DRG ELISA kit.Results There was no significant difference in age, BMI, times of deliveries, hemoglobin level, total lymphocyte count and platelet count between the cases and the controls (P＞0.05). The incidence of vitamin deficiency was 100％ in the case group and 85％ in the control group. The level of serum vitamin D was (16.63 ± 1.83) ng/ml in the case group before radiotherapy and chemotherapy, and (25.56 ± 6.64) ng/m L in the control group. The level of vitamin D before radiotherapy and chemotherapy in the case group was significantly lower than that of the control group (P＜ 0.001). The mean level of vitamin D was (11.35 ± 2.87) ng/m L after radiotherapy and was significantly lower than that before radiotherapy and chemotherapy (P＜0.001). Two different chemotherapy regimens were used in this study, FEC/T and CMF regimens. Before radiotherapy and chemotherapy, there was no significant difference in vitamin D levels between the two groups (P＞0.05). After radiotherapy and chemotherapy, vitamin D levels in both groups were significantly decreased (P＜0.001), but there was no significant difference between the two groups in vitamin D levels (P＞0.05). Multiple regression analysis showed that age, BMI and number of deliveries were significantly correlated with changes of vitamin D levels before and after radiotherapy and chemotherapy (P＜0.05), and correlations were as follows age, BMI and times of deliveries.Conclusion Vitamin D deficiency may be associated with breast cancer. Patients' age, BMI and times of deliveries were significantly correlated with vitamin D levels before and after radiotherapy and chemotherapy.