The medical laboratory issues about recommendation on uniform cutoff values of "normal" ALT in the ACG guidelines / 临床肝胆病杂志
Journal of Clinical Hepatology
;
(12): 35-38, 2018.
Artigo
em Chinês
| WPRIM
| ID: wpr-751955
ABSTRACT
In the recent American clinical guidelines dealing with laboratory tests for evaluation of liver disease, the American College of Gastroenterology (ACG) recommends ALT upper reference limits of 33 U/L for males and 25 U/L for females respectively, and that individuals with ALT above these"normal"cutoffs should be further investigated. Considering the differences between laboratory assays measuring ALT in our country, the standardization of methods and the consistency of results can not be completely ensured. The uniform "normal"range of ALT recommended by the ACG guidelines is largely based on findings from foreign studies and may not be suitable to Chinese population. On the other hand, reference upper/lower limits should not simply be equated with clinical decision thresholds. However, due to improper application of the related concepts of the above medical laboratory issues, simply recommending the uniform reference range of the ALT may lead to overdiagnosis and unnecessary follow-up examinations.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Guia de Prática Clínica
/
Estudo prognóstico
Idioma:
Chinês
Revista:
Journal of Clinical Hepatology
Ano de publicação:
2018
Tipo de documento:
Artigo
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