Urinary neutrophil gelatinase 3 associated lipocalin and nephrology in children / 中华实用儿科临床杂志

ABSTRACT

Urinary neutrophil gelatinase－associated lipocalin(uNGAL)characterizes With obvious indication of urinary epithelial injury. It is induced significantly and secreted predominantly by the injured epithelial cells of the kidney. Recent published reports have described additional utility of uNGAL in various pathologic conditions Within the pediatric urinary tract,including urinary tract infection,vesicoureteral reflux,renal scarring,and obstructive uropathy. And it Was recommended as a good biomarker for diagnosis and treatment monitoring of acute pyelonephritis in chil﹣dren. Furthermore,uNGAL is one of the earliest and most indicative biomarkers of acute kidney injury. Recent studies suggested that uNGAL excretion could be helpful in diagnosis and monitoring of treatment and progressing of various re﹣nal diseases,such as nephrotic syndrome,diabetes nephropathy,immunoglobulin A(IgA)vasculitis nephritis,lupus ne﹣phritis,et al. Additionally,the ability to assay the marker noninvasively in urine represents a significant advantage over current methods,especially for the pediatric population. These improvements Will increase the clinical utility of uNGAL and may lead to more effective and personalized treatments for children With uropoietic system diseases. The role of uNGAL in the diagnosis and treatment of children＇s kidney disease is systematically described in this article,so as to provide a reference for clinicians in their daily Work.