Analysis and prediction of clinical features of different prognosis of neonates with group B streptococcal infection / 中国小儿急救医学

ABSTRACT

Objective To analyze the risk factors leading to poor prognosis and to explore the pre-dictive value of related indicators by comparing the clinical features of different prognosis of neonates infected with Group B Streptococcus (GBS). Methods A retrospective study was performed on the clinical data of 56 neonates with GBS infection in blood culture admitted to Shengjing Hospital of China Medical University from January 2013 to December 2017. According to the clinical outcomes,the neonates were divided into sur-vival group (n＝37) and death group (n＝19). The clinical characteristics and laboratory results between the two groups were analyzed and compared. Results The gestational age and age of onset in the death group were younger than those in the survival group,the differences were statistically significant (P<0. 05). The C-reactive protein and cerebrospinal fluid leukocyte count and protein in the death group were higher than those in the survival group,and the differences were statistically significant (P<0. 05). Logistic regression multivariate analysis found that gestational age was an independent risk factor for the death of neonates infec-ted with GBS(OR＝7. 56,95%CI1. 536~37. 209). The area under the ROC curve for cerebrospinal fluid protein and white blood cell levels predicting death in children was 0. 733 ( P <0. 05 ) and 0. 723 ( P <0. 05),respectively,and the cerebrospinal fluid protein threshold was 1. 305 g/L,the threshold value of white blood cells was 1 947×106/L. Conclusion The gestational age of children with GBS infection has a very close relationship with the prognosis; cerebrospinal fluid protein and white blood cell levels have predictive value for the risk of death in children.