Correlation between serum Lp—PLA2 level and carotid atherosclerosis in patients with morning hyperten— sion / 心血管康复医学杂志

ABSTRACT

Objective:To study correlation between serum level of lipoprotein—associated phospholipase A2 (Lp—PLA2 ) and carotid atherosclerosis (AS) in patients with morning hypertension (MH ).Methods: A total of 160 MH pa—tients ,who visited or hospitalized in our department from Dec 2014 to Mar 2017 ,were selected .According to diag—nostic standard of MH ,patients were divided into MH group (n＝85) and non—MH group (n＝75).Levels of blood lipids ,fasting blood glucose (FBG ) ,serum Lp—PLA2 ,carotid intima—media thickness (IMT ) and plaque detection rate were measured and compared between two groups ,and the correlation between serum Lp—PLA2 level and carot—id AS was analyzed .Results: There were no significant difference in levels of blood lipids and FBG between two groups , P＞0.05 all.Compared with non—MH group ,there were significant rise in serum Lp—PLA2 level [ (47. 50 ± 3.15) μg／L vs.(156. 87 ± 18.56) μg／L ] ,plaque detection rate (66. 6% vs.90.6%) and carotid IMT [ (0.96 ± 0.12) mm vs.(1.26 ± 0.16) mm] in MH group , P＝0.001 all.Spearman rank correlation analysis indicated that serum Lp—PLA2 level was significant positively correlated with carotid plaque detection rate ( r＝0.532 , P＝0.003). Conclusion: Serum Lp—PLA2 level of MH patients is significantly higher than that of non—MH patients ,and it＇s sig—nificant positively correlated with carotid AS .Therefore ,the Lp—PLA2 level and atherosclerosis detections should be enhanced for early diagnosis and treatment .