Influence of comprehensive rehabilitation intervention on serum NT-proBNP level ,anxiety and depres-sion in AMI patients / 心血管康复医学杂志

ABSTRACT

Objective:To explore influence of comprehensive rehabilitation intervention on serum NT-proBNP level , anxiety and depression in AMI patients .Methods: A total of 90 AMI patients treated in our hospital were selected , randomly and equally divided into routine rehabilitation (RR) group and comprehensive rehabilitation (CR) group , both groups were intervened for six months .Serum NT-proBNP level within 6h after onset ,2d ,6d ,12d and one month after intervention ,scores of Hamilton rating scale for anxiety (HAMA) ,Hamilton rating scale for depres-sion (HAMD) and general quality of life inventory (GQOLI )-74 before ,and one ,three , six months after inter-vention were measured and compared between two groups .Results: Compared with RR group ,there was significant reduction in serum NT-proBNP level [6d (3126-33 ± 91-32 ) ng／L vs.(1799-16 ± 76-83 ) ng／L , one month(1358-91 ± 53-01) ng／L vs.(505-13 ± 38-93) ng／L] on 2d ,6d ,12d and one month after intervention , P＝0-001 all ;significant reductions in scores of HAMA and HAMD [six monthsHAMA ,(19-8 ± 1-6) scores vs.(10-3 ± 1-9) scores ;HAMD ,(20-2 ± 1-9) scores vs .(11-6 ± 1-5) scores] on three and six months after intervention , P＝0-001 all ;significant rise in scores of physical function [ (48-4 ± 1-8) scores vs .(49-7 ± 1-2) scores] and material life [ (51-5 ± 1-1) scores vs .(54-4 ± 1-9) scores] on three months after intervention ,and all dimension scores of GQOLI-74 on six months after intervention in RR group , P＝0-001 all.Conclusion: Comprehensive rehabilitation intervention can significantly reduce serum NT-proBNP level , improve anxiety and depression in AMI patients , which contributes to improving quality of life in these patients .It′s worth extending .