Correlation among plasma Hcy ,D-dimer levels and early diagnosis and staging in aged patients with myocardial infarction / 心血管康复医学杂志

ABSTRACT

Objective :To analyze value of plasma levels of homocysteine (Hcy)and D-dimer(D-D)for early diagnosis and stag-ing in aged patients with myocardial infarction (MI) and their correlation .Methods :A total of 92 aged MI patients treated in our hospital from Jan 2014 to Jun 2016 were enrolled in MI group.Another 92 healthy aged people were simultaneously regarded as healthy control group .Plasma Hcy and D-D levels were measured and compared between two groups .Diagnos-tic value of Hcy ,D-D and their combination for MI were analyzed .According to clinical staging ,MI group was further di-vided into acute stage group (n＝46) and non-acute stage group (n＝46).Levels of Hcy ,D-D ,cardiac troponin I (cTnI ) and cTnT were measured and compared between two groups ,and correlation among Hcy ,D-D levels and occurrence and staging of MI ,cTnT and cTnI levels were analyzed .Results :Compared with healthy control group ,there were significant rise in plasma levels of Hcy [(8-76 ± 2-59)μmol／L vs.(22-72 ± 10-21)μmol／L]and D-D [(229-59 ± 31-60 )μg／L vs. (1057-88 ± 250-74)μg／L]in MI group , P＝ 0-001 both .Accuracies of Hcy ,D-D and Hcy+ D-D diagnosing MI were 90-76%,84-78% and 94-02% respectively.Compared with non-acute stage group ,there were significant rise in plasma levels of Hcy ,D-D ,cTnT and cTnI in acute stage group ,P＝0-001 all.Correlation analysis indicated that plasma levels of Hcy and D-D were significant positively correlated with MI occurrence ,cTnT and cTnI levels (r＝0-875－0-951) ,and sig-nificant inversely correlated with MI staging (r＝ －0-870 ,－0-914) , P＝0-001 all.Conclusion :Hcy and D-D level detec-tions possess high accuracy for early diagnosis and clinical staging of MI .It can be extended and applied in clinic .