Therapeutic effect of probucol on patients with cerebral infarction complicated lower extremity athero‐sclerosis and its influence on Hcy level／ / 心血管康复医学杂志

ABSTRACT

To explore therapeutic effect of probucol on patients with cerebral infarction (CI) complicated lower extremity atherosclerosis (LEA) and its influence on homocysteine (Hcy) level.Methods: A total of 98 CI +LEA patients treated in our hospital were randomly divided into atorvastatin group (n＝48) and probucol group (n＝50) , After one year , levels of blood lipids , inflammatory factors and Hcy , score of United States National Institu‐tes of Health Stroke Score (NIHSS) , LEA‐related indexes before and after treatment , and incidence of adverse re‐actions were compared between two groups .Results: Compared with before treatment , after one‐year treatment , there were significant reductions in levels of blood lipids (except significant rise in HDL‐C) , inflammatory factors and Hcy , NIHSS score , intima‐media thickness (IMT ) and intimal plaque size of lower extremity arteries in two groups , P＝0. 001 all .Compared with atorvastatin group after treatment , there were significant reductions in levels of blood lipids (except significant rise in HDL‐C level) , C reactive protein [(11. 78 ± 3.02) mg／L vs.(8. 56 ± 2. 45) mg／L] , tumor necrosis factor α [(5.23 ± 1. 02) ng／L vs.(4.02 ± 0.75) ng／L] , central nervous system specific pro‐tein S100β [ (0. 45 ± 0.10) μg／L vs.(0.34 ± 0. 09) μg／L] , Hcy [ (16.58 ± 4. 19) μmol／L vs.(13.25 ± 2.87) μmol／L] , NIHSS score [ (8.99 ± 1. 35) scores vs .(7.12 ± 1. 24) scores] , IMT [ (1. 50 ± 0.28) mm vs.(1.23 ± 0.24) mm] and intimal plaque size [ (1. 35 ± 0. 22 ) cm2 vs.(0. 98 ± 0. 21) cm2 ] of lower extremity arteries in probucol group , P＝0.001 all.Incidence of adverse reactions within one year in probucol group was significantly lower than that of atorvastatin group (10. 00% vs.27. 08%, P＝0.029).Conclusion: Compared with atorvastatin , Probucol can more significantly reduce levels of blood lipids , inflammatory factors and Hcy , improve lower extremity ather‐osclerosis and neurological function injury in patients with cerebral infarction complicated lower extremity athero‐sclerosis , and it＇s safe and effective .