Risk evaluation of intracranial infection in patients treated with neuroendoscopy optic nerve tube decompression / 中国医师进修杂志

ABSTRACT

Objective To evaluate the risk of intracranial infection in patients treated with neuroendoscopy optic nerve tube decompression, and compare the risk of intracranial infection between surgery treatment and methylprednisolone treatment. Methods The clinical data of 105 patients with traumatic optic neuropathy from January 2013 to December 2017 in the First Affiliated Hospital of Zhengzhou University were retrospectively analyzed. Among them, 74 patients were treated with transsphenoidal approach neuroendoscopy optic nerve tube decompression (operation group), and cured with antibiotics during perioperative period; 31 patients were treated with intravenous methylprednisolone sodium succinate (hormone group), and combined with mouse nerve growth factor etc. Meanwhile, broad-spectrum antibiotics were used to prevent the potential infection during the first 3 d of hospitalization. The incidence of intracranial infection was compared between 2 groups. Results The incidence of intracranial infection in operation group was 4.05%(3/74), that in hormone group was 3.23%(1/31), and there was no statistical difference between 2 groups (χ2=0.127, P＞0.05). Conclusions Compared with conservative treatment, the neuroendoscopy optic nerve tube decompression has less or equivalent chance to increase the risk of intracranial infection in patients with traumatic optic neuropathy. Accordingly, it could be viewed as the first-line treatment.